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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57e8379ab1e31d6d52efc489e6c3f48a12d8acd54299bf2af94c5db573e65934' 
  AND token = 'gum6+MMCOho7D1PGFhTJWbNWsk+W5Np0Qp7PM3BqRmo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}