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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b260e1b1cbc1aa51b1fa7eea9c330f53041e11f3608343043c08319587d8b68' 
  AND token = '4Ppgwgp2jMAcrTI+f9DNSkaNEhtNfaYiTLL5OEhYUFo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}