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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '99d7f56b20063533a97de1450cf0df265d9d4fdd7d9d819b6a4ef8118f6fa0d8' 
  AND token = 'qYc6hF+3doSjsmyFWVXPyfJr3qlTbm8lOprYqHP8k5M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}