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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a80cb775f03f2bddc8f17d7a9235bafe3f9de0f08cb49525c223eaa69812c605' 
  AND token = 'QcFt9zvR5s4m48WrXCAevuBnqlvfO4YhYwsiVdt0Z94=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}