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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '454d55c43b75c67df91f9c240e6b9855d770fdd8cb243d579154b4ba9238f31d' 
  AND token = 'NsGCDIUNfMcizVlD+8bbOhjiJ3wfCdkeD1eaAV1zt3I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}