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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ab5279a01a20419a58879ceebcfc32105010c2789a4b0d3a1741aaeb1f16edf' 
  AND token = 'tK2VJ47/ZjjNUCMrX+9IoBNFCVHMQWNBppoXHJhN8bE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}