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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e6a16549995fe4a0a99d529ac2f973ab14a1aced3014aefa25f3d13f2b4a27d' 
  AND token = 'Vw8X5S5SEyIyxS3SEBaC6OPMOWIgPdTceVJcfXXTASY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}