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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46d8a5793245e7a7a6a84630a64cea8e3fd86dcd5adf115a8b6dfbaaa771f22f' 
  AND token = 'uRc/ASZ+2V2YKnFTUyD/JaFkrceit+T+0hCEa4zCTEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}