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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '354c78c9b61a672fa83958d5ce101a05e2f639e99e50775e6c02ab3d2ab5cb9e' 
  AND token = 'LQyH41jQSHRCQ/CS5r/QZywTeg5SQjiHQzM0bwo5fc8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}