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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75397f8fc52da8607f00193f66c3d416cadc5f88afb279feb05f3c01b5ab7620' 
  AND token = 'Z4sLpJEcxfTDqMK4LsPCJSSj3oT4xbMwyMWnVNTN4us=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}