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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72065680bafe4a30803534342dc657a3e2443beee4e5bdbfea14c15971af00b6' 
  AND token = 'XHvJBdtJmgk5oAY1H/aKW3tCSjHA1yqOoRLfEfPud1E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}