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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e722ccc5f1e3e8baf257f0221486f3313ff1c6f6295cb2c606f70480b678349' 
  AND token = '5r6PbYDdh35kblsIinoIl/ym6EiuDbnyz/9rCuMlIB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}