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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8843d9bb9b50e589ad5a37106cbd2db734c2a1f2a757124edbc84f8becc34f52' 
  AND token = '271wGF9qhz0Q+EfNGXEEQYFfYc3aT83EBnZDmaqc3CQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}