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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3db33d0a42c6c910e6d3e53d888275da97a17bed64b2344e28edd42363501f60' 
  AND token = 'beWhC9UAk+q3SzoLZvRQdPIkKvbpN92PMlpG5wTJMzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}