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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66498fd6412e7b9f12989f9adcb51fc3b9924045b426705f25746e959f0b085e' 
  AND token = 'XWxYWAOXJ651PsUwFdMdl262l1sssmlFhK1a+sl/isI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}