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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b4c2872c0b0bad5a0c94fae9fa4943e22bcbf547f08ec169599289e15d85da2' 
  AND token = 'JR9I5E13XR04mZ5EhpeEVwv24fi6CqF/3PbtzgBZo8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}