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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d81a0a13c85330cc8620e8f1363f406886b27a9aee2b216678cb7add2aebe1a' 
  AND token = 'fv7l9FdF/1WxERFfT40m8GVzIWuDY38vCS2qql4sHM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}