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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48858af9d96d7ed310885d9dc39b3512cf986262c1bf3256ae02f478954e61ed' 
  AND token = 'QFJy+Nv98/SZGMaNdV+Ws0d48fJyybZ1wdg3wVXm2mo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}