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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16b67dcbd7b598dfb0805dbad2ec390aa40ce1d3faca995651804d1ee12a6af3' 
  AND token = 'cXRT0XOmULQ9Yqtls4iOvE/mG+Ot8yEEGg9QArdOFTM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}