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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49f01863896dcfba1f54f07594a5765f16cc68d96f8fbe67f536e32929968c5b' 
  AND token = 'I1HALB1rDiO+6JTE63BbriPMGZBktpmbi623wypfZSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}