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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '380ce85809fdd26876184455076c646c3df9b204fe7b0df7a24c4dfbd6afb2d4' 
  AND token = 'yLbK2KK+CTU3LzX76LGKQz3N0OokNCW6Xbj7Ta7PtF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}