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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e726e437538854d3748c3889add29aca03933b2b36afae835a3fcd99e7dd19f6' 
  AND token = '3FL7mNj9PyuHiA1HzBORMNUCPifPkAcouqCH4tPsEFs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}