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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12e9b5ac9fdb7964abbd30d5e322b44fa29a7ed461d3e22a86aac307a520b900' 
  AND token = 'HdvS+p88VMegRcV2kL3kMFiHVmI7vEpUXYsSg71CcB8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}