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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e502ccf17ec5a8fc1092f2907a731ae124b5c13b7e80e15545196630d586390' 
  AND token = 'xmg+tax3Xs8OMqgO1Vc2PVeNB/PmbEBJ06d5jaYbN08=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}