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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d33d3ac106da836a7646f2dd377be2ba0ad357172fa9d2bbea01da4824964af' 
  AND token = 'jes5bE1BLjWQYKPeahydP3w+UKSoNTg4x8VCuEWJ5K0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}