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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c6dd68980832f81f997afa975844e1d1c25d7b6a87f17bc60bad5893dd16c9' 
  AND token = 'O4Zd9n+RgF6GRUxPDq+ZRm0JBmseRS5N9E527mGHl0c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}