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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221869526b00f9e98441f328b69caef3302f2aca2cae0d3a5b2ed1307e0d4a43' 
  AND token = 'td56OKMtbnL3y9lI4HKCyQJjc78t9dV1Mzu5BQzKLV0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}