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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e7b2f9fe223c00b1d47201421cc06be46d5b06346e83292200a4587e1f5ad2' 
  AND token = 'rfsSxS7Z2YLK/OSea/QdQgZ39Pp6mbHPfq6JUDHpNco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}