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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1cd2d7f1e729c0177ef4178e6e58ab984321ea024ce210409f6afec9183591d' 
  AND token = 'smgHXIPy/fuIX31JZytNkJjQAbmRCWKVGpZN5WZPy4w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}