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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43b08357ce9a5b588d440ebd65012e4e7278a40bf03a012d58e3eed98b03906e' 
  AND token = 'i0WrWP7RkXsQytQ3S6O3dbe/RPHzl22E7/t8QbFfU+Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}