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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e643fd4da915d091d54df662210b211456f707d56748f187670eb40ca8bc553e' 
  AND token = '4b+QPXI7mZ8NxxMWjiTQ9XVkOT9bhUhgD2HRm/3Wm9s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}