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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46cbec367e212eaa2d4cc144ef4a21012d5ea83b74164bf4f6053b2f60da212c' 
  AND token = 'QFnW+UY5FbA7l7Bw0WZ/jJm4CTk8ANNoKbDRwyW0zuc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}