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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52e33556b1a38b7583d428a14f2b4e82a4acd5f66a044adf7db7177d594bfa5a' 
  AND token = 'O5VKjAtkhhbSAH3iFFD3e4EkbSuI/MAe+7ql0NQrea0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}