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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6303110456e7019207400869e7aa403486968ac35eb7961a1c9422273f3716cc' 
  AND token = 'PPWbMht/aMqB4NxFtIch5A0JBmco1l/2VyH1RJuR4ps=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}