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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e21d14541ebb05338743649285eb9fe95913c13cb7e34da1f81c2e17f2b293ba' 
  AND token = 'N7Sbti8EAnY6FVZfjGU2YMXbGhCe7lmjbaXhWMpyTEE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}