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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3e449a6375318268e49fa1dbbcae3b910a7c835565ffc8e2967cc0c194d0383' 
  AND token = 'cyM1tIPAPzhWVBROhKVaqRKJz8Q33zFMy0mzz9Bbjlg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}