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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '650d6fc442f8c17cbccf256c03c9d0efad0dd758d1bee5598728c73aa030a0f6' 
  AND token = 'B22Op1UV1hrItlVia+ziewz9LuFAUHbvm93rxweoS0M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}