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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '03c2d300d266cc6e982f5311a96334477d433496582faf9d261e83b6c3021f04' 
  AND token = 'x0WYm5TdQMdjO+6IQL3cbhXs7mHEKd4Lej0cHM/ajQg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}