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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '375ea7828efad2bf7e40d28f7ba2bab1f5014c045b44f602aea0a4b51bb29681' 
  AND token = 'UM4O+fxO2hwqMMVoYYiwhqBlqRF4uSwLzet7k++HVKg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}