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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43a2d33de5a7ee9380b5dd8298691bfc976262e2c079a74d8efc1f67bb8e7c21' 
  AND token = 'TDMA8RqG6NDUqYQV5Z7MLwMioR4pOhFGM6/UL6b2zqw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}