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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e12415b3c9df8d0a1f2fefcce2412f3a2a071fef4baa683422de22a5dc7618' 
  AND token = 'curB4ZCOYFU+pRL0ijj0Z/m2snwTXe54gI0eb0bYuiY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}