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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21240cba7381ac384e5008abdd9ff0ebe17dc135be09e3668c9bf8e269e2f260' 
  AND token = 'Ejr3KS49A3x4A/smT4t5LMYUkhRK9idoBdWl+GHjDO8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}