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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed78dfccd3a6d2ba2fd3344aba6ebdfd86d8228928680a03df4ddb31ce6ca453' 
  AND token = 'kPJDws+ux0Dd4xeGBl/LsOGbeLSybUvCu9LxeBTfsDQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}