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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ede7f313453dfa4b80da2eed75293b52dabacbfb5efeb3fdbdb4d958adcb3640' 
  AND token = 'By3TnQ07WeGwO/6DBIZdsJPNHhttR1y4nnfHSG2+DF4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}