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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2581e92b0632a11dd23bba5026eb4300e9afa181a1ca73e124d17ea4165edf3' 
  AND token = 'ZZ0TC7r2WlJfksv3+OpZEJUqvKWzcbcn4L3YE0vIj2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}