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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '918792f42ce993be0d6d551a969e22e211cde3e56766aea5c0d0e1d178a41267' 
  AND token = '34hXBE6WoCm81PSSUfPz+wx/uc7R4l7Q7oMVjSuvDvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}