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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f797ab525cf7efab8be440eaced705f3636a84e554a94158ce48aeac2b0a7d8' 
  AND token = 'vnQal8o+NrzbpWzb0DOmm6vwbAA4K8LK7uWVI0azQdQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}