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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21197bdf8944b097a8fb4b9d5441e436e85aefb9cbfc9debdbcec9649f1fe1db' 
  AND token = '74CGhVXKO/T9v4nPNTwZifKNH8aJbRfup37EWefmvw0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}