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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e78533a6a073e6cef2b4ab97defb16612ff3131ee70589efb09d3db0f200070' 
  AND token = 'E4SoA3Uq7UxKAIGMd98ecU6eo4HFDNtYbTuS7t6htpE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}