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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75f4a0465538082be2b7678b2a31df64cf196cb21a64cdaa35f3d55a00501544' 
  AND token = 'POCiE2VYXQ4LfPfI+6E251clNEJSzUCL2f8S5yndKLo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}